Product Details

• Fatigue or low energy: Tiredness, reduced stamina or feeling easily depleted.
• Mood or cognitive changes: Low mood, anxiety, irritability, poor focus or memory issues.
• Chronic stress symptoms: Feeling overwhelmed, burnt out or struggling to cope with daily demands.
• Digestive discomfort: Bloating, gas, irregular bowel habits or suspected gut imbalance.
• Unexplained aches or pain: Ongoing muscle discomfort or physical tension without a clear cause.
• Inflammation-related concerns: Generalised swelling, stiffness or sensitivity.
• Sleep disturbances: Difficulty falling asleep, disrupted sleep or waking unrefreshed.
• Skin concerns: Intermittent irritation, breakouts or skin changes linked with stress or diet.
• Weight changes: Unexplained weight gain, difficulty losing weight or fluctuating weight patterns.
• Behaviour or focus issues: Inattention, restlessness or behavioural changes in children or adults.

The Organix Test provides a comprehensive assessment of key organic acids from a single urine sample. The report categorises findings across six major metabolic areas including malabsorption and dysbiosis markers, cellular energy and mitochondrial function, vitamin-related markers, neurotransmitter metabolites, toxins and detoxification pathways and oxalate markers. This wide coverage offers a broad view of metabolic activity and nutritional status.

The test can be useful when exploring patterns related to fatigue, low mood, digestive discomfort, altered stress tolerance or suspected nutrient insufficiency. By examining metabolites associated with microbial activity, mitochondrial output, B-vitamin demand, antioxidant status and detoxification load, Organix helps highlight areas where metabolic pathways may be under strain.

Organix provides a structured biochemical overview that can support clinical interpretation and help practitioners identify metabolic patterns relevant to presenting symptoms. The breadth of markers included offers a useful snapshot of functional metabolism and overall biochemical balance.

Practical

Specimen requirements:

FMV urine, Full vial  frozen

Agre requirements:

Suitable for children over 2 years old.

Methodology:
Urinary organic acids are measured via GCMS, LC/MS/MS and alkaline picrate. Reference ranges are age and gender specific and are based on a questionnaire-qualified healthy cohort. Testing is not performed in patients under 2 years old.

Downloadable research

Noninvasive urinary organic acids test to assess biochemical and nutritional individuality in autistic children

Research:

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3. Sun A-l, Ni Y-h, Li X-b, et al. Urinary methylmalonic acid as an indicator of early vitamin B12 deficiency and its role in polyneuropathy in type 2 diabetes. J Diabetes Res. 2014;2014. https://www.hindawi.com/journals/jdr/2014/921616/
4. Kwok T, Cheng G, Lai W, Poon P, Woo J, Pang C. Use of fasting urinary methylmalonic acid to screen for metabolic vitamin B12 deficiency in older persons. Nutrition. 2004;20(9):764-768.https://www.ncbi.nlm.nih.gov/pubmed/15325684
5. Brown R, Thornton MJ, Price J. The effect of vitamin supplementation on the urinary excretion of tryptophan metabolites by pregnant women. J Clin Invest. 1961;40(4):617-623. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC290765/
6. Lykouras L, Markianos M, Hatzimanolis J, Malliaras D, Stefanis C. Association of biogenic amine metabolites with symptomatology in delusional (psychotic) and nondelusional depressed patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 1995;19(5):877-887. https://www.ncbi.nlm.nih.gov/pubmed/8539425
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8. Mitochondrial Medicine Society's Committee on D, Haas RH, Parikh S, et al. The in-depth evaluation of suspected mitochondrial disease. Mol Genet Metab. 2008;94(1):16-37. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810849/
9. Dimmock DP, Lawlor MW. Presentation and Diagnostic Evaluation of Mitochondrial Disease. Pediatr Clin North Am. 2017;64(1):161-171. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130109/
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11. Jeon SW, Kim Y-K. Inflammation-induced depression: Its pathophysiology and therapeutic implications. J Neuroimmunol. 2017;313:92-98. https://www.ncbi.nlm.nih.gov/pubmed/29153615
12. Hryhorczuk LM, Novak EA, Gershon S. Gut flora and urinary phenylacetic acid. Science. 1984;226(4677):996. https://science.sciencemag.org/content/226/4677/996.1
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14. Del Rio D, Stalmach A, Calani L, Crozier A. Bioavailability of Coffee Chlorogenic Acids and Green Tea Flavan-3-ols. Nutrients. 2010;2(8):820. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257704/
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16. Caito SW, Aschner M. Mitochondrial Redox Dysfunction and Environmental Exposures. Antioxid Redox Signal. 2015;23(6):578-595. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544749/
17. Depeint F, Bruce WR, Shangari N, Mehta R, O'Brien PJ. Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism. Chem Biol Interact. 2006;163(1-2):94-112. https://www.ncbi.nlm.nih.gov/pubmed/16765926"
18. Wojtczak L, Slyshenkov VS. Protection by pantothenic acid against apoptosis and cell damage by oxygen free radicals--the role of glutathione. BioFactors. 2003;17(1-4):61-73. https://iubmb.onlinelibrary.wiley.com/doi/abs/10.1002/biof.5520170107
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21. Anderson NM, Mucka P, Kern JG, Feng H. The emerging role and targetability of the TCA cycle in cancer metabolism. Protein Cell. 2017. https://link.springer.com/article/10.1007/s13238-017-0451-1
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